GSK 143 |
| Katalog-Nr.GC50429 |
GSK 143 ist ein oral aktiver und hochselektiver Hemmer der Milz-Tyrosinkinase (SYK) mit einem pIC50 von 7,5.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1240390-27-5
Sample solution is provided at 25 µL, 10mM.
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Spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines.
Liddle et al (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 21 6188 PMID:21903390 |Varghese et al (2018) Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 182 927 PMID:28770560
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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