GSK963 |
| Katalog-Nr.GC64951 |
GSK963 ist ein chiraler, hochpotenter und selektiver Inhibitor der RIP1-Kinase mit einem IC50 von 29 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2049868-46-2
Sample solution is provided at 25 µL, 10mM.
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GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].
GSK963 is >10 000-fold selective for RIP1 over 339 other kinases, lacks measurable activity against IDO and has an inactive enantiomer, GSK962, which can be used to confirm on-target effects[1].
GSK963 (2 mg/kg) results in a complete protection from TNF+zVAD-induced temperature loss. GSK963 (0.2 mg/kg) also shows a significant response[1].
[1]. Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.
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