HUHS015 |
| Katalog-Nr.GC32804 |
HUHS015 ist ein potenter Inhibitor des Prostatakrebs-Antigen-1 (PCA-1/ALKBH3) mit einem IC50-Wert von 0,67 μM fÜr PCA-1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1453097-13-6
Sample solution is provided at 25 µL, 10mM.
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HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. [1]
[1]. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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