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IMD-0560

Katalog-Nr.GC33306

IMD-0560 ist ein neuartiger IκB-Kinase-β-Inhibitor.

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IMD-0560 Chemische Struktur

Cas No.: 439144-66-8

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10mM (in 1mL DMSO)
187,00 $
Auf Lager
1mg
66,00 $
Auf Lager
5mg
198,00 $
Auf Lager
10mg
315,00 $
Auf Lager
50mg
990,00 $
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100mg
1.260,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

IMD-0560 is a novel IκB kinase β inhibitor.

Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression[1].

The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar[1].

[1]. Tada Y, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30.

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