Imidazole Ketone Erastin (Synonyms: IKE) |
Katalog-Nr.GC52190 |
Imidazole Ketone Erastin is a ferroptosis inducer.
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Cas No.: 1801530-11-9
Sample solution is provided at 25 µL, 10mM.
Imidazole Ketone Erastin is an effective and metabolically stable system xc- inhibitor and ferroptosis inducer. Ferroptosis is a regulated form of cell death that can be induced by inhibiting the cystine-glutamate antiporter system xc- [1].
In vitro, Imidazole Ketone Erastin (0.1 nM-100 µM; 24 h) effectively reduces the number of DLBCL cells by inducing lipid peroxidation and ferroptosis, with 18 DLBCL cell lines displaying varying sensitivities to the inhibition by Imidazole Ketone Erastin [1]. Imidazole Ketone Erastin (1-250 nM; 24 h) depletes reduced glutathione in a dose-dependent manner, with an IC50 of 34 nM in SUDHL 6 cells, and also increases lipid ROS [1].
In vivo, Imidazole Ketone Erastin (23, 40 mg/kg/d; i.p.) inhibits tumor growth in a mouse model of diffuse large B cell lymphoma, leading to a significant reduction in tumor growth and body weight loss starting from day 9 [1]. Imidazole Ketone Erastin (40 mg/kg; i.p.) administered every other day for 22 days to mice with a model of chronic arthritis significantly alleviates symptoms of synovitis and promotes the rapid resolution of inflammation [2].
References:
[1]Zhang, Y., Tan, H., Daniels, J.D., et al. Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model. Cell Chem. Biol. 26(5), 623-633 (2019).
[2] TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models[J]. Nature Communications[2024-03-08].
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