iRucaparib-AP6 |
| Katalog-Nr.GC39191 |
iRucaparib-AP6 ist ein hocheffizienter und spezifischer PARP1-Abbauer auf Basis von Rucaparib unter Verwendung des PROTAC-Ansatzes. iRucaparib-AP6, ein nicht einfangender PARP1-Abbaustoff, blockiert sowohl die katalytische AktivitÄt als auch die GerÜsteffekte von PARP1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2410557-00-3
Sample solution is provided at 25 µL, 10mM.
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iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using thePROTAC approach. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1[1].
[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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