Isavuconazole |
| Katalog-Nr.: GC16707 |
Isavuconazol (BAL-4815) ist ein Triazol-Prodrug mit antimykotischer AktivitÄt gegen Hefen, Schimmelpilze und dimorphe Pilze.
Sample solution is provided at 25 µL, 10mM.
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Qualitätskontrolle & SDS
- Aktuelle Charge anzeigen:
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Reinheit: >98.00%
- COA (Zertifikat der Analyse)
- SDS (Sicherheitsdatenblatt)
- Datenblatt
Isavuconazole (BAL-4815) is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
Isavuconazole (BAL-4815) shows good activity against all Candida spp., with active MIC50 of 0.004 mg/L. The MIC50s/MIC90s range from 0.002/0.004 mg/L for C. albicans to 0.25/0.5 mg/L for C. glabrata[1]. Isavuconazole has potent in vitro activity against most common Aspergillus species, Purpureocillium lilacinum, and Scedosporium apiospermum[2]. Isavuconazole shows potent activity against molds, yeasts, and dimorphic fungi. Rhizopus isolates have MIC values to isavuconazole as low as 0.12 µg/mL with others as high as 32 µg/mL[3]. In the study of pharmacokinetics and pharmacodynamics of isavuconazole against the GFP transformant, F/11628, NIH 4215, and F/16216, the modal MICs of isavuconazole are 1, 8, 1, 4 mg/L, respectively[4].
References:
[1]. Seifert H, et al. In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. Antimicrob Agents Chemother. 2007 May;51(5):1818-21.
[2]. Steinmann J, et al. In Vitro Activity of Isavuconazole against Rasamsonia Species. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6890-6891.
[3]. Donnelley MA, et al. Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections. Infect Drug Resist. 2016 Jun 2;9:79-86.
[4]. Box H, et al. Pharmacodynamics of Isavuconazole in a Dynamic In Vitro Model of Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2015 Oct 26;60(1):278-87.
| Cas No. | 241479-67-4 | SDF | |
| Chemical Name | 4-[2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile | ||
| Canonical SMILES | CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=NC=N3)(C4=C(C=CC(=C4)F)F)O | ||
| Formula | C22H17F2N5OS | M.Wt | 437.47 |
| Löslichkeit | ≥ 19.8mg/mL in DMSO | Storage | Store at -20°C |
| Allgemeine Tipps | Um eine höhere Löslichkeit zu erreichen, erwärmen Sie das Röhrchen auf 37°C und schütteln Sie es eine Weile im Ultraschallbad. Die Stammlösung kann mehrere Monate unter -20°C gelagert werden. | ||
| Versandbedingungen | Probenlösung zur Bewertung: Lieferung mit blauem Eis Alle anderen verfügbaren Größen: Lieferung mit RT , oder blauem Eis auf Anfrage |
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