JQ-1 carboxylic acid |
| Katalog-Nr.GC19210 |
JQ-1-Carbonsäure, eine Art von (+)-JQ-1-Derivat, ist ein potenter BET-Bromodomänen-Inhibitor zur Herunterregulierung der PD-L1-Expression auf der Oberfläche von Tumorzellen. JQ-1-Carbonsäure kann als Vorstufe zur Synthese von PROTACs verwendet werden, die auf BET-Bromodomänen abzielen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 202592-23-2
Sample solution is provided at 25 µL, 10mM.
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JQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively.
References:
[1]. James Elliott Bradner, et al. Male contraceptive compositions and methods of use. Patent WO 2011143657 A1.
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