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KIF18A-IN-3

Katalog-Nr.GC64857

KIF18A-IN-3 ist ein potenter KIF18A-Inhibitor (IC50=61 nM). KIF18A-IN-3 verursacht einen signifikanten mitotischen Arrest und erhÖht die Anzahl mitotischer Zellen in Tumorgeweben. KIF18A-IN-3 kann zur Krebsforschung eingesetzt werden.

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KIF18A-IN-3 Chemische Struktur

Cas No.: 2600577-49-7

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5 mg
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10 mg
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents

KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1].

KIF18A-IN-3 (compound 24) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1].Pharmacokinetic Parameters of KIF18A-IN-3 in female CD-1 mice[1]. IP (100 mg/kg) Cmax (μM)26.5AUC0-24 (μM.h)269 C24h (μM)0.8PPB (fu)0.015

[1]. Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.

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