LCH-7749944 (Synonyms: GNF-PF-2356) |
| Katalog-Nr.GC39209 |
LCH-7749944 (GNF-PF-2356) ist ein potenter PAK4-Inhibitor mit einem IC50 von 14,93 μM. LCH-7749944 unterdrÜckt effektiv die Proliferation menschlicher Magenkrebszellen durch Herunterregulierung des PAK4/c-Src/EGFR/Cyclin-D1-Signalwegs und induziert Apoptose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 796888-12-5
Sample solution is provided at 25 µL, 10mM.
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LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].
[1]. Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317(1):24-32.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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