m-PEG9-Amine |
| Katalog-Nr.GC62673 |
m-PEG9-Amin ist ein PEG-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann. m-PEG9-Amin ist ein spaltbarer ADC-Linker, der bei der Synthese von AntikÖrper-Wirkstoff-Konjugaten (ADCs) verwendet wird.
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Cas No.: 211859-73-3
Sample solution is provided at 25 µL, 10mM.
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m-PEG9-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG9-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Xuyuan Gu, et al. Oligomer-Amino Acid Conjugates. US20120053237A1.
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