M1002 |
| Katalog-Nr.GC65046 |
M1002 ist ein Hypoxie-induzierbarer Faktor-2 (HIF-2)-Agonist und kann die Expression von HIF-2-Zielgenen verstÄrken. M1002 zeigt Synergien mit Inhibitoren der Prolyl-Hydroxylase-DomÄne (PHD).
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Cas No.: 823830-85-9
Sample solution is provided at 25 µL, 10mM.
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M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1].
M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy[1].M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors[1].
[1]. Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.
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