Mal-(CH2)5-Val-Cit-PAB-Eribulin |
| Katalog-Nr.GC63057 |
Mal-(CH2)5-Val-Cit-PAB-Eribulin ist ein Wirkstoff-Linker-Konjugat fÜr ADC mit starker AntitumoraktivitÄt durch Verwendung des Anti-Mikrotubuli-Wirkstoffs Eribulin, der Über den Linker Mal-(CH2)5-Val-Cit- PAB.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2130869-21-3
Sample solution is provided at 25 µL, 10mM.
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Mal-(CH2)5-Val-Cit-PAB-Eribulin is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-microtubule agent, Eribulin, linked via linker Mal-(CH2)5-Val-Cit-PAB[1].
Eribulin (E7389) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules[2].
[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. Patent US20170252458A1.
[2]. Watanabe K, et, al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4; 10(2): 161-174.
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