MK-3328 |
Katalog-Nr.GC31285 |
MK-3328 ist ein β-Amyloid-PET-Ligand, der mit einer IC50 von 10,5 nM eine hohe BindungsstÄrke aufweist.
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Cas No.: 1201323-97-8
Sample solution is provided at 25 µL, 10mM.
MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC50 of 10.5 nM.
MK-3328 exhibits amyloid binding potency balanced with low levels of nonspecific binding[1].
In vivo, [18F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake and good washout in normal rhesus monkey positron emission tomography (PET) imaging studies[1].
[1]. Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2(7):498-502.
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