ML372 |
| Katalog-Nr.GC64666 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1331745-61-9
Sample solution is provided at 25 µL, 10mM.
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ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1].
[1]. Mahlet B Abera, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. JCI Insight. 2016 Nov 17;1(19):e88427.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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