MLCK inhibitor peptide 18 (Synonyms: Myosin Light Chain Kinase Inhibitor Peptide 18) |
Katalog-Nr.GC17329 |
Das MLCK-Inhibitor-Peptid 18 ist ein Inhibitor der Myosin-Leichtketten-Kinase (MLCK) mit einem IC50 von 50 nM und hemmt die CaM-Kinase II nur bei 4000-fach hÖheren Konzentrationen.
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Cas No.: 224579-74-2
Sample solution is provided at 25 µL, 10mM.
MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.
MLCK inhibitor peptide 18 has a selective effect on peptide substrate utilization by MLCK, does not interfere with kinase activation by CaM, does not have significant inhibitory activity with the closely related CaMPKII, and does not inhibit PKA[1].
References:
[1]. Lukas TJ, et al. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J Med Chem. 1999 Mar 11;42(5):910-9.
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