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MLS-573151 (Synonyms: MLS000573151)

Katalog-Nr.GC13096

MLS-573151 (MLS000573151) ist ein selektiver GTPase Cdc42-Inhibitor mit einem EC50 von 2 μM.

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MLS-573151 Chemische Struktur

Cas No.: 10179-57-4

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Sample solution is provided at 25 µL, 10mM.

Description of MLS-573151

MLS-573151 is a specific and cell permeable inhibitor of Cdc42 [1].

Cdc42 is a small GTPase of the Rho family involved in regulating signaling pathways that control diverse cellular functions such as cell morphology, cell migration, cell cycle progression and endocytosis [2].

In vitro: MLS-573151 was a specific, cell permeable inhibitor of Cdc42 with an IC50 of 2 μM [1]. MLS-573151 showed no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. MLS-573151 functioned by blocking the binding of GTP to Cdc42 [1]. In marrow-derived mesenchymal stem cells, MLS-573151 showed no effect on cell migration [3].

References:
[1] Surviladze Z, Waller A, Wu Y, et al.  Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay[J]. Journal of biomolecular screening, 2010, 15(1): 10-20.
[2] Qadir M I, Parveen A, Ali M.  Cdc42: Role in Cancer Management[J]. Chemical biology & drug design, 2015, 86(4): 432-439.
[3] Wang L, Yang L, Tian L, et al.  Cannabinoid Receptor 1 Mediates Homing of Bone Marrow‐Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury[J]. Journal of cellular physiology, 2017, 232(1): 110-121.

Chemical Properties of MLS-573151

Cas No. 10179-57-4 SDF
Überlieferungen MLS000573151
Chemical Name 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide
Canonical SMILES NS(C(C=C1)=CC=C1N2C(C3=CC=CC=C3)CC(C4=CC=CC=C4)=N2)(=O)=O
Formula C21H19N3O2S M.Wt 377.5
Löslichkeit ≤20mg/ml in DMSO;30mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of MLS-573151

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1 mg 5 mg 10 mg
1 mM 2.649 mL 13.245 mL 26.4901 mL
5 mM 0.5298 mL 2.649 mL 5.298 mL
10 mM 0.2649 mL 1.3245 mL 2.649 mL
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