Necrostatin-7 (Synonyms: Nec7) |
| Katalog-Nr.GC44359 |
Necrotatin-7 (Nec-7) ist ein potenter Nekroptose-Hemmer mit einem EC50-Wert von 10,6 μM. Necrotatin-7 hemmt die rekombinante RIP1-Kinase nicht.
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Cas No.: 351062-08-3
Sample solution is provided at 25 µL, 10mM.
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Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.
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