NF 1819 |
| Katalog-Nr.GC50304 |
NF 1819 ist ein potenter und selektiver irreversibler MGL-Hemmer (β Monoacylglycerollipase auf Laktambasis).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1881244-28-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective irreversible MAGL inhibitor (IC50 values are 0.25 and 7.4 nM at rMAGL and hMAGL, respectively). Exhibits 389-fold selectivity over hFAAH and exhibits minimal binding at CB receptors (IC50 > 10 μM). Alleviates symptoms in a MS in vivo model. Exhibits analgesic effects in an acute inflammatory pain model in vivo. Ameliorates neuropathic hypersensitivity induced by oxaliplatin . Displays high membrane permeability and brain penetrant.
Brindisi et al (20106) Development and pharmacological characterization of selective blockers of 2-arachidonoyl glycerol degradation with efficacy in rodent models of multiple sclerosis and pain. J.Med.Chem. 59 2612 PMID:26888301
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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