NMDAR/TRPM4-IN-2 free base |
| Katalog-Nr.GC64521 |
Die freie Base von NMDAR/TRPM4-IN-2 (Verbindung 8) ist ein potenter Inhibitor der NMDAR/TRPM4-Interaktionsschnittstelle.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1353979-43-7
Sample solution is provided at 25 µL, 10mM.
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NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner[1].NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs[1].
[1]. Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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