O-304 |
| Katalog-Nr.GC19269 |
O-304 ist ein erster oral verfÜgbarer Pan-AMPK-Aktivator seiner Klasse, der die AMPK-AktivitÄt erhÖht, indem er die Dephosphorylierung von pAMPK unterdrÜckt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1261289-04-6
Sample solution is provided at 25 µL, 10mM.
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O-304 is a small molecule AMPK activator.
O-304 efficiently increases glucose uptake and reduces insulin resistance in skeletal muscle a primary cause of obesity-induced T2D. O-304 also reverses β-cell stress/dysfunction and induce β-cell rest. O-304 also increases energy expenditure and protects against diet induced obesity, fatty liver, hyperlipidemia and diabetes. CVD remains a major cause of death of T2 diabetics, and O-304 increases peripheral blood flow and left ventricular function, and acts as an "Exercise mimetic". Thus, as an AMPK activator O-304 uniquely mitigates many of the metabolic and cardiovascular complications associated with the obesity epidemic. O-304 has the unique potential to increase glucose uptake and reduce insulin resistance in newly diagnosed T2 diabetics and as such prevent the associated β-cell hyperactivity/failure and progression of the disease[1].
References:
[1]. Periodic Reporting for period 1-AMPK-DIAB (A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes).
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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