ONO4057 (ONO-LB457) (Synonyms: ONO-LB457) |
Katalog-Nr.GC32011 |
ONO4057 (ONO-LB457) ist ein Leukotrien-B4-Rezeptor-Antagonist mit einem IC50-Wert von 0,&7#177;0,3 ⋼M.
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Cas No.: 134578-96-4
Sample solution is provided at 25 µL, 10mM.
ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.
Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group[2].
[1]. Kishikawa K, et al. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75. [2]. Tanaka M, et al. Effect of leukotriene B(4) receptor antagonist (ONO4057) on hepatic allografting in rats. Transplant Proc. 2000 Nov;32(7):2340.
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