OTS186935 hydrochloride |
| Katalog-Nr.GC60279 |
OTS186935-Hydrochlorid ist ein potenter Protein-Methyltransferase-SUV39H2-Inhibitor mit einem IC50-Wert von 6,49 nM. OTS186935-Hydrochlorid zeigt eine signifikante Hemmung des Tumorwachstums in Maus-Xenotransplantatmodellen ohne nachweisbare ToxizitÄt. OTS193320-Hydrochlorid reguliert die Produktion von γ-H2AX in Krebszellen.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells[1].
OTS186935 hydrochloride inhibits A549 cell growth with an IC50 of 0.67 μM[1].
OTS186935 hydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models[1]. Animal Model: Female NOD.CB17-Prkdcscid/J mice (bearing MDA-MB-231 cells )[1]
[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.
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