(3S)-hydroxy Quinidine |
| Katalog-Nr.GC41694 |
(3S)-hydroxy Quinidine is an active quinidine metabolite.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53467-23-5
Sample solution is provided at 25 µL, 10mM.
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(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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