Oxcarbazepine-d4 |
| Katalog-Nr.GC46195 |
Oxcarbazepin-d4 ist Deuterium-markiertes Oxcarbazepin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1134188-71-8
Sample solution is provided at 25 µL, 10mM.
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Oxcarbazepine-d4 is intended for use as an internal standard for the quantification of oxcarbazepine by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine .1,2 It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 μM.2 Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole or picrotoxin in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.
|1. AmbrÓsio, A.F., Soares-Da-Silva, P., Carvalho, C.M., et al. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem. Res. 27(1-2), 121-130 (2002).|2. McLean, M.J., Schmutz, M., Wamil, A.W., et al. Oxcarbazepine: Mechanisms of action. Epilepsia 35(Suppl. 3), S5-S9 (1994).
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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