Teriflunomide impurity 3 (Synonyms: 4-Amino-N-(4-trifluoromethylphenyl)benzamide) |
| Katalog-Nr.GC61764 |
Teriflunomid-Verunreinigung 3 (4-Amino-N-(4-trifluormethylphenyl)benzamid) ist ein selektiver COX-1-Hemmer mit einem IC50 von 30 μM.
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Cas No.: 1011244-72-6
Sample solution is provided at 25 µL, 10mM.
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Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM)[1].
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity[1].
[1]. Hiroki Kakuta, et al. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24;51(8):2400-11.
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