PC-766B (Synonyms: Antibiotic PC-766B) |
| Katalog-Nr.GC11393 |
macrolide antibiotic
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108375-77-5
Sample solution is provided at 25 µL, 10mM.
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PC-766B is a macrolide antibiotic existed in anactinomycete strain SC-4710.
PC-766B was active against Gram-positive bacteria, and some fungi and yeasts, yet inactive against Gram-negative bacteria. PC-766B exhibited potent cytotoxicity against murine tumor cell lines in vitro. The IC50 values against P388 leukemia and B16 melanoma were 0.1 and 0.5 ng/ml, respectively [1]. Intraperitoneal administration of PC-766B (0.25mg/kg/day) showed in vivo antitumor activity against P388 leukemia. PC-766B showed a weak inhibitory activity against Na+, K+-ATPase [1].
Reference:
[1] KUMAGAI K, TAYA K, FUKUI A, et al. PC-766B, A NEW MACROLIDE ANTIBIOTIC PRODUCED BY Nocardia brasiliensis[J]. The Journal of antibiotics, 1993, 46(6): 972-978.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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