PC945 |
| Katalog-Nr.GC39635 |
PC945, ein starkes, lang wirkendes antimykotisches Triazol, ist gegen ein breites Spektrum von sowohl Azol-empfindlichen als auch Azol-resistenten StÄmmen von Aspergillus fumigatus wirksam.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1931946-73-4
Sample solution is provided at 25 µL, 10mM.
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PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively[1][2].
[1]. Colley T, et al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. [2]. Colley T, et al. Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection. Sci Rep. 2019 Jul 1;9(1):9482.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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