PD-1/PD-L1-IN-23 |
| Katalog-Nr.GC64855 |
PD-1/PD-L1-IN-23 ist ein potenter und oral aktiver Inhibitor von PD-1/PD-L1. PD-1/PD-L1-IN-23 ist ein Ester-Prodrug von L7. L7 ist ein Benzo[c][1,2,5]oxadiazol-Derivat und wurde biologisch als Inhibitor von PD-L1 bewertet. PD-1/PD-L1-IN-23 zeigt signifikante Antitumorwirkungen in Tumormodellen von syngenen und PD-L1-humanisierten MÄusen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2597056-04-5
Sample solution is provided at 25 µL, 10mM.
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PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester prodrug of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice[1].
[1]. Liu L, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021;64(12):8391-8409.
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