PF-04745637 |
| Katalog-Nr.GC64573 |
PF-04745637 ist ein potenter und selektiver TRPA1-Antagonist mit einem IC50-Wert von 17 nM fÜr humanes TRPA1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1917294-46-2
Sample solution is provided at 25 µL, 10mM.
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PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].
Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].
[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.
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