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Pitofenone (hydrochloride)

Katalog-Nr.GC18207 Copy One-Click Copy Product Info

Pitofenon (Hydrochlorid), eine spasmolytische Verbindung, hemmt die Acetylcholinesterase (AChE)-Aktivität von Rindererythrozyten und Zitteraal mit Kis von 36 bzw. 45 μM.

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Pitofenone (hydrochloride) Chemische Struktur

Cas No.: 1248-42-6

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10mM (in 1mL DMSO)
50,00 $
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1mg
17,00 $
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5mg
45,00 $
Auf Lager
10mg
72,00 $
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25mg
144,00 $
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50mg
234,00 $
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100mg
378,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.



Description of Pitofenone (hydrochloride)

Pitofenone is an antispasmodic agent and an inhibitor of acetylcholinesterase (AChE; Kis = 36 and 45 μM for bovine erythrocyte and electric eel enzyme, respectively). It inhibits acetylcholine-induced contractions of isolated guinea pig ileum when used at a concentration of 2.5 μM.

Chemical Properties of Pitofenone (hydrochloride)

Cas No. 1248-42-6 SDF
Chemical Name 2-[4-[2-(1-piperidinyl)ethoxy]benzoyl]-benzoic acid, methyl ester, monohydrochloride
Canonical SMILES O=C(C1=CC=CC=C1C(OC)=O)C(C=C2)=CC=C2OCCN3CCCCC3.Cl
Formula C22H25NO4.HCl M.Wt 403.9
Löslichkeit DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Pitofenone (hydrochloride)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4759 mL 12.3793 mL 24.7586 mL
5 mM 495.2 μL 2.4759 mL 4.9517 mL
10 mM 247.6 μL 1.2379 mL 2.4759 mL
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In vivo Formulation Calculator (Clear solution) of Pitofenone (hydrochloride)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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