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Prostaglandin B2-d4 (Synonyms: PGB2d4)

Katalog-Nr.GC47984 Copy One-Click Copy Product Info

An internal standard for the quantification of prostaglandin B2

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Prostaglandin B2-d4 Chemische Struktur

Cas No.: 211105-23-6

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50 μg
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100 μg
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500 μg
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1 mg
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Sample solution is provided at 25 µL, 10mM.



Description of Prostaglandin B2-d4

Prostaglandin B2 (PGB2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGB2 by GC- or LC-mass spectrometry. PGB2 is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 mg/kg).1

1.Liu, F., Orr, J.A., and Wu, J.Y.Prostaglandin B2-induced pulmonary hypertension is mediated by TXA2/PGH2 receptor stimulationJournal of the American Physiological Society1040L602-L607(1994)

Chemical Properties of Prostaglandin B2-d4

Cas No. 211105-23-6 SDF
Überlieferungen PGB2d4
Canonical SMILES O=C1C(C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)=C(/C=C/[C@@H](O)CCCCC)CC1
Formula C20H26D4O4 M.Wt 338.5
Löslichkeit DMF: >75 mg/ml (from PGB2),DMSO: >50 mg/ml (from PGB2),Ethanol: >100 mg/ml (from PGB2),PBS pH 7.2: >2 mg/ml (from PGB2) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Prostaglandin B2-d4

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.9542 mL 14.771 mL 29.5421 mL
5 mM 590.8 μL 2.9542 mL 5.9084 mL
10 mM 295.4 μL 1.4771 mL 2.9542 mL
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In vivo Formulation Calculator (Clear solution) of Prostaglandin B2-d4

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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