PROTAC Bcl-xL degrader-2 |
| Katalog-Nr.GC63769 |
PROTAC Bcl-xL-Degrader-2 ist ein potenter Bcl-xL-Degrader (Mitglied der Bcl-2-Familie) auf der Basis von von Hippel-Lindau-Liganden mit einem IC50-Wert von 0,6 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC50 of 0.6 nM.
PROTAC Bcl-xL degrader-2 (PROTAC 6; 0.1 nM-10 μM; 24 hours) treatment decreases the level of Bcl-xL protein in THP-1 cells[1].PROTAC Bcl-xL degrader-2 (PROTAC 6) inhibits caspase 3/7 activity in MOLT-4 cells with an IC50 of 466 nM[1].
[1]. Chun-Wa Chung, et al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.
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