Pyrimethanil

Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops[1]. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection[3].

Pyrimethanil is a strobilurin fungicide belonging to the anilinopyrimidine class. Pyrimethanil (5 and 50 µg/L) elicits a range of toxic responses, has the potential to induce histological alterations in tissues of the Italian tree frog H. intermedia after a long term exposure to two environmentally relevant concentrations of Pyrimethanil[2].Pyrimethanil decreases polygalacturonase, cellulase, proteinase and laccase activities in the medium of three day‐old cultures. The pyrimethanil results in 50% reduction (IC50) in total enzyme activities are approximately 0.25 μM for polygalacturonase, cellulase and proteinase, and approximately 1.0 μM for laccase[3].

[1]. Petr Masner, et al. Possible methionine biosynthesis inhibition by pyrimidinamine fungicides. Pesticide Science [2]. L Kanetis, et al. Characterization of genetic and biochemical mechanisms of fludioxonil and pyrimethanil resistance in field isolates of Penicillium digitatum. Phytopathology [3]. Richard J. Milling, et al. Mode of action of the anilino‐pyrimidine fungicide pyrimethanil. 2. Effects on enzyme secretion in Botrytis cinerea. Volume45, Issue1, September 1995. [4]. Salvatore D'Aquino, et al. Residue levels and effectiveness of pyrimethanil vs imazalil when using heated postharvest dip treatments for control of Penicillium decay on citrus fruit. J Agric Food Chem. 2006 Jun 28;54(13):4721-6.