p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
Produkte für p53
- Bestell-Nr. Artikelname Informationen
- GC11445 YH239-EE YH239-EE, Ethylester der freien CarbonsÄureverbindung YH239, ist ein potenter p53-MDM2-antagonisierender und Apoptose-induzierender Wirkstoff.
- GC18677 YMU1 YMU1 ist ein selektiver Inhibitor der humanen Thymidylatkinase (hTMPK) mit einem IC50 von 610 nM.
- GN10203 Ziyuglycoside I