SNIPER(BRD)-1 |
| Katalog-Nr.GC65574 |
SNIPER(BRD)-1 besteht aus einem LCL-161-Derivat des IAP-Antagonisten und einem BET-Inhibitor (+)-JQ-1, die durch einen Linker verbunden sind. SNIPER(BRD)-1 induziert den Abbau von BRD4 Über den Ubiquitin-Proteasom-Weg. SNIPER(BRD)-1 baut auch cIAP1, cIAP2 und XIAP mit IC50-Werten von 6,8 nM, 17 nM bzw. 49 nM ab.
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Cas No.: 2095244-54-3
Sample solution is provided at 25 µL, 10mM.
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SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].
[1]. Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209.
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