SPT Imidazopyridine 1 |
| Katalog-Nr.GC50328 |
SPT Imidazopyridin 1 (Verbindung 1) ist ein oral aktiver und potenter SPT (Serin-Palmitoyl-Transferase)-Inhibitor mit einem IC50-Wert von 5,19 nM fÜr hSPT1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1933533-18-6
Sample solution is provided at 25 µL, 10mM.
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Potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.
Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID:27213958
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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