Sugemalimab |
| Katalog-Nr.GC65580 |
Sugemalimab ist ein vollstÄndig humaner, monoklonaler AntikÖrper (mAb) gegen den programmierten Todesliganden 1 (PD-L1) Immunglobulin G4 (IgG4) in voller LÄnge. Sugemalimab zeigt AntikrebsaktivitÄten und kann fÜr die Erforschung von nicht-kleinzelligem Lungenkrebs verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2256084-03-2
Sample solution is provided at 25 µL, 10mM.
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Sugemalimab is a fully human, full length, anti-programmed death ligand 1 (PD-L1) immunoglobulin G4 (IgG4) monoclonal antibody (mAb). Sugemalimab shows anticancer activities and can be used for non-small cell lung cancer research[1].
Sugemalimab (CS1001) specifically binds to PD-L1, competitively blocks the binding of human PD-L1 with PD-1 and CD80, and effectively induces CD4+ T lymphocyte proliferation and enhances the production of interferon-γ and interleukin-2[2].Sugemalimab employs IgG4 isotype and lacks antibody-dependent cellular mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC)[2].
Sugemalimab (CS1001) signifcantly inhibits tumor growth in the subcutaneous MC38-hPD-L1 murine colon carcinoma (murine MC38 cells expressing human PD-L1) in human PD-1 knock-in mouse model[2].Sugemalimab not only enhances the cytotoxic T cell/regulatory T cell ratio, but also significantly upregulates M1 macrophage and down-regulated MDSC (myeloid-derived suppressor cells) population in D-1/PD-L1 dual knock-in mice implanted with MC38-hPD-L1 tumor[2].
[1]. Dhillon S, et al. Sugemalimab: First Approval. Drugs. 2022 Apr;82(5):593-599.
[2]. Zhang J, et al. The preclinical characterization of CS1001, an anti-PD-L1 IgG4 monoclonal antibody and its activity beyond T cell regulation. Cancer Research, 2020, 80(16_Supplement): 3260-3260.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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