SW-100 |
| Katalog-Nr.GC64968 |
SW-100, ein selektiver Inhibitor der Histon-Deacetylase 6 (HDAC6) mit einem IC50 von 2,3 nM, zeigt eine mindestens 1000-fache SelektivitÄt fÜr HDAC6 im Vergleich zu allen anderen HDAC-Isozymen.
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Cas No.: 2126744-35-0
Sample solution is provided at 25 µL, 10mM.
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SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].
SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner[1].
SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome[1].
[1]. Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.
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