Swinholide A |
| Katalog-Nr.GC44976 |
Swinholid A ist das aktinbindende marine Polyketid und dimerisiert Aktin mit einer Kd von ~ 50 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 95927-67-6
Sample solution is provided at 25 µL, 10mM.
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Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells. [1] [2] It stabilizes actin dimers and also binds to and severs F-actin filaments.[1] [3] Swinholide A binds to G-actin in a 1:2 molar ratio and decreases the rate of nucleotide exchange in G-actin. [2]
Reference:
[1]. Bubb, M.R., Spector, I., Bershadsky, A.D., et al. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. The Journal of Biological Chemisty 270(8), 3463-3466 (1995).
[2]. Saito, S.y., Watabem, S., Ozaki, H., et al. Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A. Journal of Biochemistry 123(4), 571-578 (1998).
[3]. Terry, D.R., Higa, T., and Bubb, M.R. Misakinolide A is a marine macrolide that caps but does not sever filamentous actin. The Journal of Biological Chemisty 272(12), 7841-7845 (1997)
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