Tamsulosin hydrochloride (Synonyms: LY253351, YM-12617-1) |
| Katalog-Nr.GC50035 |
Tamsulosinhydrochlorid ((R)-(-)-YM12617) ist ein Inhibitor des α1-adrenergen Rezeptors.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 106463-17-6
Sample solution is provided at 25 µL, 10mM.
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Selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo.
Garcia-Sainz et al (1995) Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 289 1 PMID:7781702 |Taguchi et al (1997) Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 280 1 PMID:8996174 |Ohtake et al (2005) Effects of tamsu. on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 58 345
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