TAN 1364B (Synonyms: RK-682 (rac-1)) |
| Katalog-Nr.GC41443 |
TAN 1364B, ein Racemat von RK-682, ist ein Inhibitor der Proteintyrosinphosphatase (PTPase). TAN 1364B hemmt Protein-Tyrosin-Phosphatase 1B (PTP-1B), Protein-Tyrosin-Phosphatase mit niedrigem Molekulargewicht (LMW-PTP) und Zellteilungszyklus 25B (CDC-25B) mit IC50-Werten von 8,6 μM, 12,4 μM und 0,7 μM.
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Cas No.: 154639-24-4
Sample solution is provided at 25 µL, 10mM.
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TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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