TAT-cyclo-CLLFVY |
| Katalog-Nr.GC50211 |
TAT-cyclo-CLLFVY ist ein zyklischer Peptid-Hemmer der HIF-1-Heterodimerisierung, der die Hypoxie-SignalÜbertragung in Krebszellen hemmt. TAT-cyclo-CLLFVY unterbricht die HIF-1α/HIF-1β-Protein-Protein-Wechselwirkung mit einem IC50 von 1,3 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1446322-66-2
Sample solution is provided at 25 µL, 10mM.
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Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.
Miranda et al (2013) A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 135 10418 PMID:23796364
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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