Thalidomide-NH-PEG2-C2-NH-Boc |
| Katalog-Nr.GC39675 |
Thalidomide-NH-PEG2-C2-NH-Boc ist ein synthetisiertes E3-Ligase-Ligand-Linker-Konjugat, das den auf Thalidomid basierenden Cereblon-Liganden und einen PEG-Linker enthÄlt, der fÜr die Synthese von dBRD9 (Verbindung 6) verwendet wird. dBRD9 ist ein selektiver BRD9-Sonden-PROTAC-Degrader fÜr die Untersuchung der BAF-Komplexbiologie.
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Cas No.: 2097509-40-3
Sample solution is provided at 25 µL, 10mM.
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Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1].
[1]. David Remillard, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.2017 May 15;56(21):5738-5743.
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