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Thiothixene (Synonyms: CP 12,252-1, NSC 108165, P 4657B, cis-Thiothixene)

Katalog-Nr.GC18797 Copy One-Click Copy Product Info

Thiothixene is a typical antipsychotic.

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Thiothixene Chemische Struktur

Cas No.: 5591-45-7

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1mg
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5mg
707,00 $
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Sample solution is provided at 25 µL, 10mM.



Description of Thiothixene

Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis = 0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis = 15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis = 3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats. Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior. Formulations containing thiothixene have been used in the treatment of schizophrenia and bipolar mania.

Chemical Properties of Thiothixene

Cas No. 5591-45-7 SDF
Überlieferungen CP 12,252-1, NSC 108165, P 4657B, cis-Thiothixene
Chemical Name N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide
Canonical SMILES CN1CCN(CC/C=C2C(C=CC=C3)=C3SC4=C\2C=C(S(N(C)C)(=O)=O)C=C4)CC1
Formula C23H29N3O2S2 M.Wt 443.6
Löslichkeit DMF: 0.5 mg/ml,DMSO: 0.2 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Thiothixene

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1 mg 5 mg 10 mg
1 mM 2.2543 mL 11.2714 mL 22.5428 mL
5 mM 450.9 μL 2.2543 mL 4.5086 mL
10 mM 225.4 μL 1.1271 mL 2.2543 mL
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In vivo Formulation Calculator (Clear solution) of Thiothixene

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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