Umibecestat (Synonyms: CNP520) |
| Katalog-Nr.GC65361 |
Umibecestat (CNP520) ist ein Beta-Site Amyloid Precursor Protein Cleaving Enzyme-1 (BACE-1)-Inhibitor mit IC50-Werten von 11 nM und 10 nM fÜr menschliches BACE-1 bzw. Maus-BACE-1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1387560-01-1
Sample solution is provided at 25 µL, 10mM.
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Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively[1]. Umibecestat can be used for the research of alzheimer's disease.
Umibecestat (CNP520) is a potent BACE-1 inhibitor that is selective for BACE-1 over other human pepsin-like aspartic proteases, including BACE-2 and cathepsin D[1].
Umibecestat (CNP520) (1.5-51.3 mg/kg; given by oral gavage; 72 hours) shows a dose-dependent effects on Aβ40 and a long duration of action in both rat brain and CSF[1].Umibecestat (CNP520) (3.1 mg/kg; oral administration; 7 days) shows a > 75% reduction on Aβ40 and Aβ42 in CSF after dosing and returns slowly to baseline over the next 7 days[1].
[1]. Neumann U, et al. The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. EMBO Mol Med. 2018 Nov;10(11). pii: e9316.
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