Valopicitabine dihydrochloride (Synonyms: NM283 dihydrochloride) |
| Katalog-Nr.GC63635 |
Valopicitabin (NM283) Dihydrochlorid ist ein Nukleosid-Analogon und das oral bioverfÜgbare Prodrug des potenten Anti-HCV-Wirkstoffs 2'-C-Methylcytidin (NM107).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 640725-71-9
Sample solution is provided at 25 µL, 10mM.
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Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable prodrug of the potent anti-HCV agent 2’-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination[1][2].
Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) dihydrochloride shows the Cmax, AUC, t1/2, and tmax were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively[2].
[1]. Liu-Young G, et al. Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008;22(6):449-457.
[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2’-C-methylcytidine. J Med Chem. 2006;49(22):6614-6620.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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