VHL Ligand 8 |
| Katalog-Nr.GC60379 |
VHL-Ligand 8 ist ein VHL-Ligand. VHL-Ligand 8 kann zur Synthese von ARD-266 verwendet werden, einem hochwirksamen und auf VHL-E3-Ligase basierenden Androgenrezeptor (AR)-PROTAC-Abbaumittel. ARD-266 induziert effektiv den Abbau des AR-Proteins in AR-positiven LNCaP-, VCaP- und 22Rv1-Prostatakrebszelllinien mit DC50-Werten von 0,2-1 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 , a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM[1].
[1]. Han X, Zhao L, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.
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