VU 0409106 |
| Katalog-Nr.GC50144 |
VU 0409106 ist ein potenter und selektiver mGlu5 negativer allosterischer Modulator (NAM) mit einem IC50 von 24 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1276617-62-9
Sample solution is provided at 25 µL, 10mM.
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Potent and selective mGlu5 negative allosteric modulator (IC50 = 49 nM at human mGlu5). Selective for mGlu5 over a panel of GPCRs and ion channels. Exhibits no significant nonspecific binding in rat brain homogenates in vitro. Inhibits marble burying behavior in mice. Brain penetrant.
Felts et al (2013) Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg.Med.Chem.Lett. 23 5779 PMID:24074843
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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