VU0238441 |
| Katalog-Nr.GC61378 |
VU0238441 ist ein panmuskarinischer Acetylcholinrezeptor (mAChR) positiver allosterischer Modulator (PAM) mit EC50s von 3,2 μM, 2,8 μM, 2,2 μM, 2,1 μM, >10 μM fÜr M1, M2, M3, M5 bzw. M4[ 2].
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 85511-68-8
Sample solution is provided at 25 µL, 10mM.
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VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].
VU0238441 is an analogue of VU0119498[2].
[1]. Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. [2]. Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8.
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